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Alnylam Pharmaceuticals

HQ: Cambridge, MA source · alnylam.com ↗ · New England

FDA-approved therapeutic company Clinical Phase 3

115 open jobs · last seen Oct 23, 2026 · 54 sources

Keywords: neurology cardiovascular metabolic RNA therapeutics hereditary systemic amyloidosis 1 rare diseases cardiovascular diseases Hypertension Acute Hepatic Porphyria Type 2 Diabetes Mellitus (T2DM) Transthyretin Amyloidosis (ATTR) With Cardiomyopathy Hereditary Amyloidosis Primary Hyperoxaluria TTR-mediated Amyloidosis Transthyretin Amyloidosis With Cardiomyopathy Primary Hyperoxaluria Type 1 High Cardiovascular Risk Obesity Transthyretin-Mediated Amyloidosis Transthyretin Amyloidosis Primary Hyperoxaluria Type 1 (PH1) Familial Amyloid Neuropathies Familial Amyloid Polyneuropathies Amyloid Neuropathies Amyloidosis, Hereditary, Transthyretin-Related Acute Intermittent Porphyria Hereditary Transthyretin-mediated (hATTR) Amyloidosis Polyneuropathy Alzheimer's Disease Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy hATTR-PN Von Willebrand Disease Heavy Menstrual Bleeding High Risk Cardiovascular Disease Cerebral Amyloid Angiopathy Hereditary Hemorrhagic Telangiectasia Huntington's Disease Early-Onset Alzheimer Disease ATTR Amyloidosis Down Syndrome-Associated Alzheimer's Disease Transthyretin-Related Hereditary Amyloidosis Asymptomatic Carrier State Advanced Hepatocellular Carcinoma Metastatic Hepatocellular Carcinoma Mild to Moderate Hypertension IgA Nephropathy

Profile checked Oct 10, 2026

115Open jobs84Trials (company is sponsor)1FDA records (2 yrs)3NIH grants

Hiring

TitleLocation (from posting)Employer postedFirst seen
Senior Manager, HCP Marketing, US Congress LeadUnited StatesOct 22, 2026Oct 23, 2026
Principal Scientist, Biotransformation and Metabolite ProfilingUnited StatesOct 21, 2026Oct 22, 2026
Senior Director, Commercial OperationsCambridge, MAOct 21, 2026Oct 22, 2026
Manager, Global Patient Safety & Risk MgmntCambridge, MAOct 16, 2026Oct 17, 2026
Associate Director, Identity & Access Management ArchitectCambridge, MAOct 15, 2026Oct 16, 2026

See all 115 jobs

Trial and FDA signals

Job counts as of Oct 18, 2026. All trial and FDA signals

Timeline

  1. Trial start Phase 2: A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD) source ↗
  2. Trial start 2: HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB source ↗
  3. Trial start Phase 1: A Study to Evaluate ALN-6222 in Participants With Obesity source ↗
  4. Trial start Phase 2: A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran source ↗
  5. Trial start Phase 1/Phase 2: A Study to Evaluate ALN-2232 in Participants With Obesity source ↗
  6. Trial start Phase 1: A Study to Evaluate ALN-4915 in Adult Healthy Volunteers source ↗
  7. Trial start Phase 3: TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy source ↗
  8. Trial start Phase 2: A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus source ↗
  9. Trial start —: DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting source ↗
  10. Trial start Phase 1: A Study to Evaluate ALN-4285 in Adult Healthy Volunteers source ↗
  11. Debt Debt financing announced Dec 11, 2025. Source: SEC filing. source ↗
  12. Trial start Phase 1: A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease source ↗
  13. Trial start Phase 3: Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease source ↗
  14. Debt Debt: $575M (not counted as a raise), announced Sep 9, 2025. Source: SEC filing. source ↗
  15. Trial start Phase 3: TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy source ↗
  16. FDA FDA New indication / efficacy supplement: AMVUTTRA (vutrisiran sodium) — NDA215515/6, Mar 20, 2025. Applicant at approval: Alnylam Pharmaceuticals, Inc. source ↗
  17. Trial start Phase 1/Phase 2: A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM source ↗
  18. Trial start Phase 1: A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma source ↗
  19. Trial start Phase 3: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy source ↗
  20. Trial start Phase 1/Phase 2: A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT) source ↗
  21. Trial start Phase 1: A Study to Evaluate ALN-AGT01 RVR in Adult Healthy Volunteers source ↗
  22. Trial start Phase 1: A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease source ↗
  23. Trial start Phase 1/Phase 2: A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension source ↗
  24. Trial start 2: A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy source ↗
  25. Trial start —: Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloi source ↗

Showing 25 of 51 dated events.

Upcoming milestones

Estimated primary completion per ClinicalTrials.gov. Dates move.

Funding

Debt: $575.0M. Last 2 years.

Clinical trials (lead sponsor) Showing 50 of 84

RecordTitlePhaseStatusStartPrimary completion
NCT07358078DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World SettingNot listedRecruitingJan 9, 2026Oct 23, 2030 (estimated)
NCT05040373Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance ProgramNot listedRecruitingAug 1, 2020Oct 12, 2030 (estimated)
NCT07214727A Study to Evaluate ALN-5288 in Patients With Alzheimer's DiseasePhase 1RecruitingOct 15, 2025Mar 6, 2030 (estimated)
NCT07223203TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With PolyneuropathyPhase 3RecruitingFeb 3, 2026Dec 27, 2027 (estimated)
NCT07553442A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With ZilebesiranPhase 2RecruitingApr 27, 2026Apr 1, 2028 (estimated)
NCT04982393BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)Not listedActive, not recruitingDec 13, 2021Jan 2, 2029 (estimated)
NCT04883905ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)Not listedRecruitingApr 26, 2021Dec 31, 2030 (estimated)
NCT07575308HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB2RecruitingJul 30, 2026Jun 30, 2027 (estimated)
NCT07181109Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular DiseasePhase 3RecruitingSep 22, 2025Sep 23, 2030 (estimated)
NCT06393712A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy2Active, not recruitingMay 17, 2024Aug 9, 2027 (estimated)
NCT07295717A Study to Evaluate ALN-4285 in Adult Healthy VolunteersPhase 1RecruitingDec 12, 2025Dec 29, 2026 (estimated)
NCT07052903TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With CardiomyopathyPhase 3RecruitingJul 2, 2025May 28, 2030 (estimated)
NCT07463846A Study to Evaluate ALN-2232 in Participants With ObesityPhase 1/Phase 2RecruitingMar 2, 2026Apr 27, 2027 (estimated)
NCT07535606A Study to Evaluate ALN-4915 in Adult Healthy VolunteersPhase 1RecruitingMar 2, 2026Jul 31, 2027 (estimated)
NCT07465224A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes MellitusPhase 2RecruitingJan 15, 2026May 28, 2027 (estimated)
NCT06845202A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DMPhase 1/Phase 2Active, not recruitingMar 3, 2025Aug 31, 2027 (estimated)
NCT06659640A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)Phase 1/Phase 2Active, not recruitingNov 7, 2024Jan 5, 2028 (estimated)
NCT06585449A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's DiseasePhase 1RecruitingOct 14, 2024Jul 5, 2028 (estimated)
NCT05231785A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOADPhase 1RecruitingFeb 4, 2022Apr 20, 2029 (estimated)
NCT04561518ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)Not listedRecruitingNov 23, 2020Dec 31, 2033 (estimated)
NCT07636811A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)Phase 2RecruitingAug 17, 2026May 18, 2030 (estimated)
NCT07624071A Study to Evaluate ALN-6222 in Participants With ObesityPhase 1RecruitingJun 4, 2026Dec 14, 2027 (estimated)
NCT06360289Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With PolyneuropathyNot listedActive, not recruitingApr 25, 2024Dec 15, 2027 (estimated)
NCT06600321A Study to Evaluate ALN-BCAT in Patients With Hepatocellular CarcinomaPhase 1RecruitingDec 30, 2024Sep 30, 2027 (estimated)
NCT06423352A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate HypertensionPhase 1/Phase 2CompletedJun 5, 2024Jul 17, 2025 (actual)
NCT03997383APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)Phase 3CompletedSep 4, 2019Jun 20, 2022 (actual)
NCT06272487Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)Phase 2CompletedFeb 29, 2024Jun 19, 2025 (actual)
NCT06679946A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyPhase 3Enrolling by invitationDec 3, 2024Mar 31, 2028 (estimated)
NCT05661916A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy SubjectsPhase 1CompletedJan 16, 2023Sep 30, 2025 (actual)
NCT04153149HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyPhase 3Active, not recruitingNov 26, 2019May 8, 2024 (actual)
NCT03759379HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)Phase 3CompletedFeb 14, 2019Nov 10, 2020 (actual)
NCT04936035A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate HypertensionPhase 2CompletedJul 7, 2021Apr 4, 2023 (actual)
NCT05103332Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)Phase 2CompletedNov 5, 2021Dec 11, 2023 (actual)
NCT06675565A Study to Evaluate ALN-AGT01 RVR in Adult Healthy VolunteersPhase 1CompletedNov 5, 2024Sep 8, 2025 (actual)
NCT04152200A Study to Evaluate Lumasiran in Patients With Advanced Primary Hyperoxaluria Type 1Phase 3CompletedJan 21, 2020May 18, 2021 (actual)
NCT05761301A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM1TerminatedMar 10, 2023Apr 3, 2025 (actual)
NCT03905694A Study of Lumasiran in Infants and Young Children With Primary Hyperoxaluria Type 1Phase 3CompletedApr 22, 2019Jun 29, 2020 (actual)
NCT03681184A Study to Evaluate Lumasiran in Children and Adults With Primary Hyperoxaluria Type 1Phase 3CompletedNov 27, 2018Nov 5, 2019 (actual)
NCT03841448A Study of Cemdisiran in Adults With Immunoglobulin A Nephropathy (IgAN)Phase 2TerminatedSep 30, 2019Mar 17, 2022 (actual)
NCT05161936A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate LevelsPhase 2TerminatedJan 27, 2022Nov 1, 2022 (actual)
NCT04056481Expanded Access Protocol of Givosiran for Patients With Acute Hepatic PorphyriaNot listedApproved for marketingNot listedNot listed
NCT02939820Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)Not listedApproved for marketingNot listedNot listed
NCT04565717A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH)Phase 1TerminatedOct 9, 2020Jan 6, 2023 (actual)
NCT03350451An Extension Study of an Investigational Drug, Lumasiran (ALN-GO1), in Participants With Primary Hyperoxaluria Type 1Phase 2CompletedApr 4, 2018Feb 7, 2023 (actual)
NCT03338816ENVISION: A Study to Evaluate the Efficacy and Safety of Givosiran (ALN-AS1) in Patients With Acute Hepatic Porphyrias (AHP)Phase 3CompletedNov 16, 2017Jan 31, 2019 (actual)
NCT01960348APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated AmyloidosisPhase 3Completed2013-112017-08 (actual)
NCT03862807Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver TransplantPhase 3CompletedMar 27, 2019Oct 6, 2020 (actual)
NCT01617967Safety and Tolerability of Patisiran (ALN-TTR02) in Transthyretin (TTR) AmyloidosisPhase 2Completed2012-052013-10 (actual)
NCT01961921The Study of ALN-TTR02 (Patisiran) for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Who Have Already Been Treated With ALN-TTR02 (Patisiran)Phase 2Completed2013-102016-07 (actual)
NCT05256810A Study to Evaluate ALN-XDH in Healthy Subjects and Patients With GoutPhase 1/Phase 2TerminatedFeb 25, 2022Jan 25, 2023 (actual)

FDA records (last 2 years)

NIH awards 3

Annual award amounts. Total $9.4M.

Raises and investors new

Form D raises come from the company’s own SEC filing (last 2 years).

Open jobs 115

TitleLocation (from posting, not HQ)Employer postedFirst seenLevel
Senior Manager, HCP Marketing, US Congress LeadUnited StatesOct 22, 2026Oct 23, 2026Not stated
Principal Scientist, Biotransformation and Metabolite ProfilingUnited StatesOct 21, 2026Oct 22, 2026Not stated
Senior Director, Commercial OperationsCambridge, MAOct 21, 2026Oct 22, 2026Not stated
Manager, Global Patient Safety & Risk MgmntCambridge, MAOct 16, 2026Oct 17, 2026Not stated
Associate Director, Identity & Access Management ArchitectCambridge, MAOct 15, 2026Oct 16, 2026Not stated
Area Sales Manager, Northeast GermanyGermanyOct 15, 2026Oct 16, 2026Not stated
Senior Director, ToxicologyUnited StatesOct 15, 2026Oct 16, 2026Not stated
Vice President, Early Pipeline DeliveryUnited StatesOct 14, 2026Oct 15, 2026Executive
Associate Director, Program ManagementCambridge, MAOct 14, 2026Oct 15, 2026Senior
Associate Scientist II, Bioanalytical SciencesCambridge, MAOct 13, 2026Oct 14, 2026Mid
Clinical Operations & Regulatory Placement StudentMaidenhead, United KingdomOct 12, 2026Oct 14, 2026Entry
Medical & Commercial Placement StudentMaidenhead, United KingdomOct 12, 2026Oct 14, 2026Entry
Sr Director, IT - Ethics, Compliance & Legal TechnologyCambridge, MAOct 9, 2026Oct 12, 2026Senior
Submit Your Resume for Future Opportunities at Alnylam's Norton Manufacturing SiteNorton MAOct 9, 2026Oct 12, 2026Not stated
Director, Product DevelopmentCambridge, MAOct 9, 2026Oct 12, 2026Senior
Regional Business Director, TTR - South Central (Atlanta, AL, LA, AR, MS)United StatesOct 8, 2026Oct 12, 2026Senior
Business Account Executive, TTR - Orlando, FLUnited StatesOct 8, 2026Oct 12, 2026Mid
Business Account Executive, Rare Disease - Upstate New YorkUnited StatesOct 8, 2026Oct 12, 2026Mid
Sr. Manager, Medical Science Liaison - Community, Pacific West (CA, WA, OR, HI, AK, ID, NV, UT, MT)United StatesOct 8, 2026Oct 12, 2026Senior
Associate Director, Regulatory & Pharmaceutical Affairs (Chief Pharmaceutical Officer Deputy)Paris, FranceOct 7, 2026Oct 12, 2026Executive
Associate Director of Marketing, KOL Engagement and EnablementUnited StatesOct 6, 2026Oct 12, 2026Senior
Senior Director, US Strategic AccountsUnited StatesOct 6, 2026Oct 12, 2026Senior
Lead Manufacturing TechnicianNorton, MAOct 6, 2026Oct 12, 2026Senior
Field Reimbursement Manager - Great Lakes NorthMinneapolis, MN, St. Paul, MN, Madison, WI, Milwaukee, WIOct 6, 2026Oct 12, 2026Mid
Sr. Director, HCP TTR MarketingCambridge, MassachusettsOct 5, 2026Oct 12, 2026Senior
Sr. Manager, Clinical OperationsUnited StatesOct 5, 2026Oct 12, 2026Senior
Director, Global Market AccessCambridge, MassachusettsOct 2, 2026Oct 12, 2026Senior
Associate Director, Commercial Consent, Identity & Preference ManagementCambridge, MAOct 2, 2026Oct 12, 2026Senior
Quality Control Analyst IIINorton, MAOct 1, 2026Oct 12, 2026Mid
VP, Global Trial OptimizationCambridge, MAOct 1, 2026Oct 12, 2026Executive
VP, Strategic PlanningCambridge, MAOct 1, 2026Oct 12, 2026Executive
Associate Director, Clinical PharmacologyUnited StatesSep 30, 2026Oct 12, 2026Senior
Director, Regulatory Affairs, Global Labeling Strategy (US)United StatesSep 30, 2026Oct 12, 2026Senior
Scientist, Biocatalysis & Protein EngineeringCambridge, MASep 29, 2026Oct 12, 2026Senior
Senior Director, Global Environmental Health, Safety and SustainabilityCambridge, MASep 29, 2026Oct 12, 2026Senior
Associate Director, Commercial Technology & Data EngineeringCambridge, MASep 29, 2026Oct 12, 2026Senior
Associate Medical Director, Global Safety Medical ReviewUnited StatesSep 29, 2026Oct 12, 2026Senior
Senior Director, Global Pharmacovigilance Quality Assurance LeadCambridge, MA; Philadelphia, PA; VirtualSep 28, 2026Oct 12, 2026Senior
Sr. Manager, Clinical OperationsMaidenhead, UKSep 28, 2026Oct 12, 2026Senior
Director, Digital HR PlatformsCambridge, MASep 25, 2026Oct 12, 2026Senior
Associate Director, Scientific Communications Strategy & ExcellenceUnited StatesSep 24, 2026Oct 12, 2026Senior
Director, Regulatory TechnologyCambridge, MASep 24, 2026Oct 12, 2026Senior
Quality Control Analyst II-Weekend ShiftNorton, MASep 23, 2026Oct 12, 2026Mid
Key Account Manager, BarcelonaBarcelona, SpainSep 23, 2026Oct 12, 2026Mid
Field Reimbursement Manager - NorthwestSeattle, Washington, United StatesSep 22, 2026Oct 12, 2026Mid
Sr. Manager, Regulatory AffairsMaidenhead, United KingdomSep 22, 2026Oct 12, 2026Senior
Director, Platform InfrastructureCambridge, MASep 21, 2026Oct 12, 2026Senior
Associate Director, Regulatory StrategyMaidenhead, United KingdomSep 21, 2026Oct 12, 2026Senior
Associate Director, Cyber Defense - Staff Incident ResponderCambridge, MASep 21, 2026Oct 12, 2026Senior
Director, Ethics and Compliance, AI & Technology GovernanceCambridge, MASep 17, 2026Oct 12, 2026Senior

Level (Entry/Mid/Senior/Executive) is estimated from the job title and required years of experience. Descriptions are short excerpts (about the first 60 words) of the posting plus skills picked out of it; use Read full posting for the complete text.

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