COMPANY

OrthoTrophix

Profile checked Oct 10, 2026

Keywords: Knee Osteoarthritis Osteoarthritis (OA) of the Knee Mild to Moderate Knee OA TPX-100

Timeline

May 9, 2025 Trial start Phase 2: 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee source ↗
Jul 27, 2017 Trial start —: A Prospective Observational Study to Evaluate Long-term Changes in Cartilage Morphology in Subjects Who Previously Received TPX-100 or Placebo in Study TPX-100-1 for Patellar Osteoarthritis Involvi source ↗
2016-08 Trial start Phase 2: A Study Evaluating the Safety and Efficacy of a Second Course of TPX-100 in Subjects Who Previously Received TPX-100 for Patellar Osteoarthritis Involving Both Knees source ↗
2014-01 Trial start Phase 2: A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees source ↗

Mar 25, 2027 (ESTIMATED) · Phase 2 · 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee · NCT06865079

Estimated primary completion per ClinicalTrials.gov. Dates move.

Record	Title	Phase	Status	Start	Primary completion
NCT06865079	53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee	Phase 2	Active, not recruiting	May 9, 2025	Mar 25, 2027 (estimated)
NCT03125499	A Prospective Observational Study to Evaluate Long-term Changes in Cartilage Morphology in Subjects Who Previously Received TPX-100 or Placebo in Study TPX-100-1 for Patellar Osteoarthritis Involving Both Knees	Not listed	Completed	Jul 27, 2017	Oct 1, 2017 (actual)
NCT02837900	A Study Evaluating the Safety and Efficacy of a Second Course of TPX-100 in Subjects Who Previously Received TPX-100 for Patellar Osteoarthritis Involving Both Knees	Phase 2	Completed	2016-08	2017-08 (actual)
NCT01925261	A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees	Phase 2	Completed	2014-01	2016-09 (actual)