COMPANY

PathMaker Neurosystems

Keywords: neurology neuromodulation Stroke Amyotrophic Lateral Sclerosis ALS - Amyotrophic Lateral Sclerosis Muscle Spasticity Multi-site direct current stimulation (DCS) MyoRegulator®

Profile checked Oct 10, 2026

3Trials (company is sponsor)5NIH grants

Timeline

Feb 10, 2025 Trial start Not phased (device or behavioral study): Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study source ↗
Jun 21, 2023 Trial start Not phased (device or behavioral study): Early Feasibility Study of the MyoRegulator® for Treatment of ALS source ↗
Mar 4, 2022 Trial start Not phased (device or behavioral study): Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity source ↗

Upcoming milestones

2026-10 (ESTIMATED) · Not phased · Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study · NCT06649955

Estimated primary completion per ClinicalTrials.gov. Dates move.

Clinical trials (lead sponsor) 3

Record	Title	Phase	Status	Start	Primary completion
NCT06649955	Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study	Not phased (device or behavioral study)	Recruiting	Feb 10, 2025	2026-10 (estimated)
NCT06165172	Early Feasibility Study of the MyoRegulator® for Treatment of ALS	Not phased (device or behavioral study)	Completed	Jun 21, 2023	Jul 31, 2024 (actual)
NCT04742257	Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity	Not phased (device or behavioral study)	Terminated	Mar 4, 2022	Jun 30, 2024 (actual)

NIH awards 5

Annual award amounts. Total $5.3M.

Jul 26, 2022 NIH award 5U44NS104138-04 FY2022: $1,434,858 awarded for that fiscal year; activity U44 (SBIR); PI YAGHOUBI, NADER; recipient as written: PATHMAKER NEUROSYSTEMS, INC., BOSTON, MA. MyoRegulator: A Non-Invasive Neuromo source ↗
Sep 15, 2021 NIH award 1R41NS125872-01 FY2021: $371,628 awarded for that fiscal year; activity R41 (STTR); PI AHMED, ZAGHLOUL; recipient as written: PATHMAKER NEUROSYSTEMS, INC., BOSTON, MA. Multi-path DCS as a novel non-invasive source ↗
Jun 10, 2021 NIH award 4U44NS104138-03 FY2021: $1,462,521 awarded for that fiscal year; activity U44 (SBIR); PI YAGHOUBI, NADER; recipient as written: PATHMAKER NEUROSYSTEMS, INC., BOSTON, MA. MyoRegulator: A Non-Invasive Neuromo source ↗
Feb 13, 2019 NIH award 5U44NS104138-02 FY2019: $1,036,705 awarded for that fiscal year; activity U44 (SBIR); PI YAGHOUBI, NADER; recipient as written: PATHMAKER NEUROSYSTEMS, INC., BOSTON, MA. MyoRegulator: A non-invasive neuromo source ↗
Feb 2, 2018 NIH award 1U44NS104138-01 FY2018: $997,932 awarded for that fiscal year; activity U44 (SBIR); PI YAGHOUBI, NADER; recipient as written: PATHMAKER NEUROSYSTEMS, INC., BOSTON, MA. MyoRegulator: A non-invasive neuromodu source ↗