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Cytokinetics

HQ: South San Francisco, CA source · cytokinetics.com ↗ · West Coast

FDA-approved therapeutic company Clinical Phase 3

86 open jobs · last seen Oct 23, 2026 · 52 sources

Location: South San Francisco, CA · source · Oct 15, 2026

Keywords: Heart Failure Heart Failure With Reduced Ejection Fraction Amyotrophic Lateral Sclerosis Symptomatic Obstructive Hypertrophic Cardiomyopathy Obstructive Hypertrophic Cardiomyopathy Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF) Pediatric Hypertrophic Cardiomyopathy Symptomatic Hypertrophic Cardiomyopathy (HCM) QT Intervals Changes QTc Intervals Changes Left Ventricular Systolic Dysfunction Chronic Heart Failure History of Chronic Heart Failure Left Ventricular Ejection Fraction Echocardiogram Chronic Heart Failure With Reduced Ejection Fraction Spinal Muscular Atrophy Non-Hodgkin's Lymphoma Hodgkin's Disease Myasthenia Gravis Intermittent Claudication Peripheral Artery Disease Breast Neoplasms Myocardial Ischemia Angina Pectoris malaria Reldesemtiv Omecamtiv Mecarbil Aficamten tirasemtiv SB-743921 CK-4021586

Since the raise (May 8, 2026): 86 of 86 open jobs were first seen after it.

86Open jobs$805.0MRaised (2 yrs)41Trials (company is sponsor)1FDA records (2 yrs)7NIH grants

Hiring

TitleLocation (from posting)Employer postedFirst seen
Senior ScientistSouth San Francisco, CaliforniaOct 22, 2026Oct 23, 2026
Associate Director, Business Insights & Analytics Data ScientistRadnor, PennsylvaniaOct 22, 2026Oct 23, 2026
Senior Manager, CMC Analytical ChemistrySouth San Francisco, CaliforniaOct 22, 2026Oct 23, 2026
Senior Manager, IT Technical SecuritySouth San Francisco, CaliforniaOct 22, 2026Oct 23, 2026
Associate Director, Business Insights & AnalyticsRadnor, PennsylvaniaOct 22, 2026Oct 23, 2026

See all 86 jobs

Trial and FDA signals

Job counts as of Oct 18, 2026. All trial and FDA signals

Timeline

  1. Board tracked Radar started tracking this company’s job board (86 open jobs at last check). source ↗
  2. Raise Follow-on offering: $805M (total, as published), announced May 8, 2026. Source: company release on GlobeNewswire. source ↗
  3. FDA FDA New drug/biologic (novel): MYQORZO (aficamten) — NDA219083, Dec 19, 2025. Applicant at approval: Cytokinetics, Incorporated. source ↗
  4. Debt Debt: $650M (not counted as a raise), announced Sep 16, 2025. Source: SEC filing. source ↗
  5. Trial start Phase 2: AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF source ↗
  6. Trial start Phase 3: Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction source ↗
  7. Trial start Phase 2/Phase 3: A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). source ↗
  8. Trial start Phase 3: A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) source ↗
  9. Trial start 3: Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM source ↗
  10. Trial start Phase 1: Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval source ↗
  11. Trial start Phase 1: A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants source ↗
  12. Trial start Phase 1: A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants source ↗
  13. Trial start 3: A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) source ↗
  14. Trial start 3: Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM source ↗
  15. Trial start Phase 3: A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) source ↗
  16. Trial start Phase 2/Phase 3: Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM source ↗
  17. Trial start Phase 3: Omecamtiv Mecarbil Post-trial Access Study source ↗
  18. Trial start Phase 2: Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy source ↗
  19. Trial start Phase 1: Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults source ↗
  20. Trial start Phase 3: Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure source ↗
  21. Trial start Phase 1: A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects source ↗
  22. Trial start Phase 2: A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS) source ↗
  23. Trial start Phase 3: Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction source ↗
  24. Trial start Phase 3: A Study for Patients Who Completed VITALITY-ALS (CY 4031) source ↗
  25. Trial start Phase 2: Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction source ↗

Showing 25 of 45 dated events.

Upcoming milestones

Estimated primary completion per ClinicalTrials.gov. Dates move.

Open jobs 86

TitleLocation (from posting, not HQ)Employer postedFirst seenLevel
Senior ScientistSouth San Francisco, CaliforniaOct 22, 2026Oct 23, 2026Not stated
Associate Director, Business Insights & Analytics Data ScientistRadnor, PennsylvaniaOct 22, 2026Oct 23, 2026Not stated
Senior Manager, CMC Analytical ChemistrySouth San Francisco, CaliforniaOct 22, 2026Oct 23, 2026Not stated
Senior Manager, IT Technical SecuritySouth San Francisco, CaliforniaOct 22, 2026Oct 23, 2026Not stated
Associate Director, Business Insights & AnalyticsRadnor, PennsylvaniaOct 22, 2026Oct 23, 2026Not stated
Cardiovascular Account Specialist - U.S. Sales, San Antonio, TXRemoteOct 22, 2026Oct 23, 2026Not stated
Associate Director, Patient Support Services OperationsRadnor, PennsylvaniaOct 20, 2026Oct 21, 2026Not stated
Senior Quality Assurance Specialist - Drug SubstanceSouth San Francisco, CaliforniaOct 19, 2026Oct 5, 2026Senior
Senior Quality Assurance Specialist - Drug ProductRadnor, PennsylvaniaOct 19, 2026Oct 5, 2026Senior
Manager, Quality Systems - GxP Training (Contract)South San Francisco, CaliforniaOct 19, 2026Oct 5, 2026Mid
Director, Quality SystemsSouth San Francisco, CaliforniaOct 19, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - SoutheastRemoteOct 19, 2026Oct 5, 2026Senior
Director, QA Operations3 locations (listed on the posting)Oct 19, 2026Oct 5, 2026Senior
Senior Scientist II, Statistical GeneticsSouth San Francisco, CaliforniaOct 19, 2026Oct 20, 2026Not stated
Director, Clinical Quality AssuranceSouth San Francisco, CaliforniaOct 16, 2026Oct 5, 2026Senior
Senior Director, Medical Safety & Pharmacovigilance2 locations (listed on the posting)Oct 16, 2026Oct 5, 2026Senior
Principal Scientist, Translational BiologySouth San Francisco, CaliforniaOct 16, 2026Oct 16, 2026Not stated
Order to Cash Manager, Europe (6 months contract position)IrelandOct 13, 2026Oct 5, 2026Senior
Senior Director, BiostatisticsSouth San Francisco, CaliforniaOct 13, 2026Oct 14, 2026Senior
Executive Director and Head of Alliance ManagementSouth San Francisco, CaliforniaOct 12, 2026Oct 5, 2026Executive
Director, Commercial Regulatory EuropeZug, SwitzerlandOct 9, 2026Oct 10, 2026Senior
Director, Quality Operations, Supply Chain Oversight & EU Responsible PersonIrelandOct 8, 2026Oct 5, 2026Senior
Key Account Manager, Cardiovascular (Munich, Germany)Remote - GermanyOct 8, 2026Oct 8, 2026Mid
Medical Director, US Medical Affairs, HCM2 locations (listed on the posting)Oct 7, 2026Oct 5, 2026Senior
Senior Quality Assurance Specialist - Drug ProductIrelandOct 6, 2026Oct 6, 2026Senior
Senior Quality Assurance Specialist - Drug SubstanceIrelandOct 6, 2026Oct 6, 2026Senior
Senior Pharmacovigilance Operations ManagerSouth San Francisco, CaliforniaOct 5, 2026Oct 5, 2026Senior
Senior Legal Counsel, EuropeIrelandOct 2, 2026Oct 5, 2026Senior
Director, Corporate Securities & Governance CounselSouth San Francisco, CaliforniaOct 2, 2026Oct 5, 2026Senior
Senior Director, Legal CounselSouth San Francisco, CaliforniaOct 2, 2026Oct 5, 2026Senior
Cardiovascular Account Specialist - U.S. Sales, Pasadena, CARemoteSep 30, 2026Oct 5, 2026Mid
Cardiovascular Account Specialist - U.S. Sales, Arlington, VA2 locations (listed on the posting)Sep 28, 2026Oct 5, 2026Mid
Director, HCP Personal Promotion Marketing2 locations (listed on the posting)Sep 23, 2026Oct 5, 2026Senior
Senior Manager, Healthcare ComplianceRadnor, PennsylvaniaSep 23, 2026Oct 5, 2026Senior
Scientist IISouth San Francisco, CaliforniaSep 23, 2026Oct 5, 2026Mid
Senior Manager, Regulatory Affairs CMCRadnor, PennsylvaniaSep 23, 2026Oct 5, 2026Senior
Senior Manager, Regulatory Operations & SystemsSouth San Francisco, CaliforniaSep 23, 2026Oct 5, 2026Senior
Scientist ISouth San Francisco, CaliforniaSep 23, 2026Oct 5, 2026Entry
Senior Manager, Regulatory Operations - SystemsRadnor, PennsylvaniaSep 23, 2026Oct 5, 2026Senior
Director, US Regulatory Affairs, Advertising & PromotionRadnor, PennsylvaniaSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - Southern CaliforniaRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - Rocky MountainRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - Mid SouthRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - New York CityRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - Pacific CoastRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - Gulf CoastRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - NortheastRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - Mid AtlanticRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - AlleghenyRemoteSep 23, 2026Oct 5, 2026Senior
Field Access Manager (FAM) - Southern FloridaRemoteSep 23, 2026Oct 5, 2026Senior

Level (Entry/Mid/Senior/Executive) is estimated from the job title and required years of experience. Descriptions are short excerpts (about the first 60 words) of the posting plus skills picked out of it; use Read full posting for the complete text.

All 86 jobs →

Funding

Raised: $805.0M · Debt: $650.0M. Last 2 years.

Clinical trials (lead sponsor) 41

RecordTitlePhaseStatusStartPrimary completion
NCT06736574Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection FractionPhase 3RecruitingDec 19, 20242027-09 (estimated)
NCT06081894A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)Phase 3Active, not recruitingAug 31, 2023Aug 31, 2026 (actual)
NCT06793371AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEFPhase 2RecruitingFeb 6, 20252026-09 (estimated)
NCT06412666A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).Phase 2/Phase 3Active, not recruitingMay 29, 20242030-01 (estimated)
NCT05767346Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM3CompletedJun 20, 2023Feb 28, 2025 (actual)
NCT05186818Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM3CompletedFeb 1, 2022Nov 10, 2023 (actual)
NCT04219826Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic CardiomyopathyPhase 2CompletedJan 10, 2020Feb 28, 2023 (actual)
NCT04848506Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCMPhase 2/Phase 3Enrolling by invitationMay 6, 20212028-03 (estimated)
NCT05877053A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult ParticipantsPhase 1CompletedMay 9, 2023Nov 20, 2024 (actual)
NCT04175808Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy AdultsPhase 1CompletedNov 14, 2019Mar 4, 2020 (actual)
NCT03767855A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult SubjectsPhase 1CompletedDec 4, 2018Jan 3, 2020 (actual)
NCT04944784A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)Phase 3TerminatedAug 16, 2021Jul 18, 2023 (actual)
NCT05662215A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult ParticipantsPhase 1TerminatedDec 6, 2022Aug 8, 2023 (actual)
NCT05442775A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031)3TerminatedAug 4, 2022Jun 7, 2023 (actual)
NCT05924815Study to Evaluate the Effect of Aficamten Administration on QT/QTc IntervalPhase 1CompletedMay 15, 2023Nov 14, 2023 (actual)
NCT03759392Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart FailurePhase 3CompletedApr 9, 2019Nov 8, 2021 (actual)
NCT02929329Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection FractionPhase 3CompletedJan 6, 2017Sep 14, 2020 (actual)
NCT01786512COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart FailurePhase 2CompletedFeb 26, 2013Jul 22, 2015 (actual)
NCT01077167Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure PatientsPhase 2Withdrawn2010-072011-05 (actual)
NCT01737866Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal InsufficiencyPhase 1Completed2012-112013-01 (actual)
NCT04464525Omecamtiv Mecarbil Post-trial Access StudyPhase 3WithdrawnDec 18, 2020Nov 27, 2026 (estimated)
NCT02601001Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese AdultsPhase 1CompletedNov 13, 2015Jan 6, 2016 (actual)
NCT01300013Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)Phase 2Completed2011-042013-04 (actual)
NCT02695420Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection FractionPhase 2CompletedApr 14, 2016Apr 6, 2017 (actual)
NCT02936635A Study for Patients Who Completed VITALITY-ALS (CY 4031)Phase 3CompletedOct 17, 2016Oct 26, 2018 (actual)
NCT00624442A Study of CK-1827452 Infusion in Stable Heart FailurePhase 2Completed2007-042009-02 (actual)
NCT03160898A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)Phase 2CompletedJul 24, 2017Mar 7, 2019 (actual)
NCT02496767Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a YearPhase 3CompletedSep 3, 2015Mar 9, 2017 (actual)
NCT02644668A Study of CK-2127107 in Patients With Spinal Muscular AtrophyPhase 2CompletedJan 14, 2016May 31, 2018 (actual)
NCT01709149Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)Phase 2Completed2012-102014-03 (actual)
NCT00748579Phase II Study of the Effect of CK-1827452 Injection on Myocardial EfficiencyIITerminated2008-092008-11 (actual)
NCT00343564A Study of SB-743921 in Non-Hodgkin Lymphoma and Hodgkin LymphomaPhase 1/Phase 2Completed2006-042010-07 (actual)
NCT01268280Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia GravisPhase 2Terminated2010-122012-10 (actual)
NCT01131013A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic ClaudicationPhase 2Completed2010-052011-03 (actual)
NCT01089010A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)Phase 2Completed2010-032010-11 (actual)
NCT01378676A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)Phase 2Completed2011-062012-03 (actual)
NCT00607841A Study of Ispinesib in Metastatic Breast CancerPhase 1Terminated2007-122009-11 (actual)
NCT01486849Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)Phase 2Completed2011-112012-03 (actual)
NCT00682565PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and AnginaPhase 2Completed2008-042008-11 (actual)
NCT01380223A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy VolunteersPhase 1Completed2005-082006-04 (actual)
NCT00941681Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart FailurePhase 2Completed2009-042009-10 (actual)

FDA records (last 2 years)

NIH awards 7

Annual award amounts. Total $4.0M.

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