COMPANY
Cytokinetics
FDA-approved therapeutic company Clinical Phase 3
Since the raise (May 8, 2026): 86 of 86 open jobs were first seen after it.
Hiring
| Title | Location (from posting) | Employer posted | First seen |
|---|---|---|---|
| Senior Scientist | South San Francisco, California | Oct 22, 2026 | Oct 23, 2026 |
| Associate Director, Business Insights & Analytics Data Scientist | Radnor, Pennsylvania | Oct 22, 2026 | Oct 23, 2026 |
| Senior Manager, CMC Analytical Chemistry | South San Francisco, California | Oct 22, 2026 | Oct 23, 2026 |
| Senior Manager, IT Technical Security | South San Francisco, California | Oct 22, 2026 | Oct 23, 2026 |
| Associate Director, Business Insights & Analytics | Radnor, Pennsylvania | Oct 22, 2026 | Oct 23, 2026 |
Trial and FDA signals
- Drug approval + hiring FDA novel approval for MYQORZO (NDA 219083, Dec 19, 2025); 49 manufacturing/quality or commercial roles open. FDA NDA 219083 (Dec 19, 2025)
Evidence (1 event)
- Dec 19, 2025 · FDA NDA 219083
openFDA drugsfda: application_number=NDA219083; sponsor_name='CYTOKINETICS'; submission_type=ORIG; submission_number=1; submission_status=AP; submission_status_date=20251219; submission_class_code=TYPE 1; brand_name=['MYQORZO']
- Dec 19, 2025 · FDA NDA 219083
Timeline
- Board tracked Radar started tracking this company’s job board (86 open jobs at last check). source ↗
- Raise Follow-on offering: $805M (total, as published), announced May 8, 2026. Source: company release on GlobeNewswire. source ↗
- FDA FDA New drug/biologic (novel): MYQORZO (aficamten) — NDA219083, Dec 19, 2025. Applicant at approval: Cytokinetics, Incorporated. source ↗
- Debt Debt: $650M (not counted as a raise), announced Sep 16, 2025. Source: SEC filing. source ↗
- Trial start Phase 2: AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF source ↗
- Trial start Phase 3: Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction source ↗
- Trial start Phase 2/Phase 3: A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). source ↗
- Trial start Phase 3: A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) source ↗
- Trial start 3: Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM source ↗
- Trial start Phase 1: Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval source ↗
- Trial start Phase 1: A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants source ↗
- Trial start Phase 1: A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants source ↗
- Trial start 3: A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) source ↗
- Trial start 3: Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM source ↗
- Trial start Phase 3: A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) source ↗
- Trial start Phase 2/Phase 3: Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM source ↗
- Trial start Phase 3: Omecamtiv Mecarbil Post-trial Access Study source ↗
- Trial start Phase 2: Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy source ↗
- Trial start Phase 1: Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults source ↗
- Trial start Phase 3: Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure source ↗
- Trial start Phase 1: A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects source ↗
- Trial start Phase 2: A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS) source ↗
- Trial start Phase 3: Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction source ↗
- Trial start Phase 3: A Study for Patients Who Completed VITALITY-ALS (CY 4031) source ↗
- Trial start Phase 2: Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction source ↗
Upcoming milestones
- 2027-09 (ESTIMATED) · Phase 3 · Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction · NCT06736574
- 2028-03 (ESTIMATED) · Phase 2/Phase 3 · Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM · NCT04848506
- 2030-01 (ESTIMATED) · Phase 2/Phase 3 · A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). · NCT06412666
Open jobs 86
| Title | Location (from posting, not HQ) | Employer posted | First seen | Level |
|---|---|---|---|---|
| Senior Scientist | South San Francisco, California | Oct 22, 2026 | Oct 23, 2026 | Not stated |
| Associate Director, Business Insights & Analytics Data Scientist | Radnor, Pennsylvania | Oct 22, 2026 | Oct 23, 2026 | Not stated |
| Senior Manager, CMC Analytical Chemistry | South San Francisco, California | Oct 22, 2026 | Oct 23, 2026 | Not stated |
| Senior Manager, IT Technical Security | South San Francisco, California | Oct 22, 2026 | Oct 23, 2026 | Not stated |
| Associate Director, Business Insights & Analytics | Radnor, Pennsylvania | Oct 22, 2026 | Oct 23, 2026 | Not stated |
| Cardiovascular Account Specialist - U.S. Sales, San Antonio, TX | Remote | Oct 22, 2026 | Oct 23, 2026 | Not stated |
| Associate Director, Patient Support Services Operations | Radnor, Pennsylvania | Oct 20, 2026 | Oct 21, 2026 | Not stated |
| Senior Quality Assurance Specialist - Drug Substance | South San Francisco, California | Oct 19, 2026 | Oct 5, 2026 | Senior |
| Senior Quality Assurance Specialist - Drug Product | Radnor, Pennsylvania | Oct 19, 2026 | Oct 5, 2026 | Senior |
| Manager, Quality Systems - GxP Training (Contract) | South San Francisco, California | Oct 19, 2026 | Oct 5, 2026 | Mid |
| Director, Quality Systems | South San Francisco, California | Oct 19, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Southeast | Remote | Oct 19, 2026 | Oct 5, 2026 | Senior |
| Director, QA Operations | 3 locations (listed on the posting) | Oct 19, 2026 | Oct 5, 2026 | Senior |
| Senior Scientist II, Statistical Genetics | South San Francisco, California | Oct 19, 2026 | Oct 20, 2026 | Not stated |
| Director, Clinical Quality Assurance | South San Francisco, California | Oct 16, 2026 | Oct 5, 2026 | Senior |
| Senior Director, Medical Safety & Pharmacovigilance | 2 locations (listed on the posting) | Oct 16, 2026 | Oct 5, 2026 | Senior |
| Principal Scientist, Translational Biology | South San Francisco, California | Oct 16, 2026 | Oct 16, 2026 | Not stated |
| Order to Cash Manager, Europe (6 months contract position) | Ireland | Oct 13, 2026 | Oct 5, 2026 | Senior |
| Senior Director, Biostatistics | South San Francisco, California | Oct 13, 2026 | Oct 14, 2026 | Senior |
| Executive Director and Head of Alliance Management | South San Francisco, California | Oct 12, 2026 | Oct 5, 2026 | Executive |
| Director, Commercial Regulatory Europe | Zug, Switzerland | Oct 9, 2026 | Oct 10, 2026 | Senior |
| Director, Quality Operations, Supply Chain Oversight & EU Responsible Person | Ireland | Oct 8, 2026 | Oct 5, 2026 | Senior |
| Key Account Manager, Cardiovascular (Munich, Germany) | Remote - Germany | Oct 8, 2026 | Oct 8, 2026 | Mid |
| Medical Director, US Medical Affairs, HCM | 2 locations (listed on the posting) | Oct 7, 2026 | Oct 5, 2026 | Senior |
| Senior Quality Assurance Specialist - Drug Product | Ireland | Oct 6, 2026 | Oct 6, 2026 | Senior |
| Senior Quality Assurance Specialist - Drug Substance | Ireland | Oct 6, 2026 | Oct 6, 2026 | Senior |
| Senior Pharmacovigilance Operations Manager | South San Francisco, California | Oct 5, 2026 | Oct 5, 2026 | Senior |
| Senior Legal Counsel, Europe | Ireland | Oct 2, 2026 | Oct 5, 2026 | Senior |
| Director, Corporate Securities & Governance Counsel | South San Francisco, California | Oct 2, 2026 | Oct 5, 2026 | Senior |
| Senior Director, Legal Counsel | South San Francisco, California | Oct 2, 2026 | Oct 5, 2026 | Senior |
| Cardiovascular Account Specialist - U.S. Sales, Pasadena, CA | Remote | Sep 30, 2026 | Oct 5, 2026 | Mid |
| Cardiovascular Account Specialist - U.S. Sales, Arlington, VA | 2 locations (listed on the posting) | Sep 28, 2026 | Oct 5, 2026 | Mid |
| Director, HCP Personal Promotion Marketing | 2 locations (listed on the posting) | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Senior Manager, Healthcare Compliance | Radnor, Pennsylvania | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Scientist II | South San Francisco, California | Sep 23, 2026 | Oct 5, 2026 | Mid |
| Senior Manager, Regulatory Affairs CMC | Radnor, Pennsylvania | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Senior Manager, Regulatory Operations & Systems | South San Francisco, California | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Scientist I | South San Francisco, California | Sep 23, 2026 | Oct 5, 2026 | Entry |
| Senior Manager, Regulatory Operations - Systems | Radnor, Pennsylvania | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Director, US Regulatory Affairs, Advertising & Promotion | Radnor, Pennsylvania | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Southern California | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Rocky Mountain | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Mid South | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - New York City | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Pacific Coast | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Gulf Coast | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Northeast | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Mid Atlantic | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Allegheny | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
| Field Access Manager (FAM) - Southern Florida | Remote | Sep 23, 2026 | Oct 5, 2026 | Senior |
Funding
Clinical trials (lead sponsor) 41
| Record | Title | Phase | Status | Start | Primary completion |
|---|---|---|---|---|---|
| NCT06736574 | Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction | Phase 3 | Recruiting | Dec 19, 2024 | 2027-09 (estimated) |
| NCT06081894 | A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) | Phase 3 | Active, not recruiting | Aug 31, 2023 | Aug 31, 2026 (actual) |
| NCT06793371 | AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF | Phase 2 | Recruiting | Feb 6, 2025 | 2026-09 (estimated) |
| NCT06412666 | A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). | Phase 2/Phase 3 | Active, not recruiting | May 29, 2024 | 2030-01 (estimated) |
| NCT05767346 | Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM | 3 | Completed | Jun 20, 2023 | Feb 28, 2025 (actual) |
| NCT05186818 | Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM | 3 | Completed | Feb 1, 2022 | Nov 10, 2023 (actual) |
| NCT04219826 | Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy | Phase 2 | Completed | Jan 10, 2020 | Feb 28, 2023 (actual) |
| NCT04848506 | Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM | Phase 2/Phase 3 | Enrolling by invitation | May 6, 2021 | 2028-03 (estimated) |
| NCT05877053 | A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants | Phase 1 | Completed | May 9, 2023 | Nov 20, 2024 (actual) |
| NCT04175808 | Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults | Phase 1 | Completed | Nov 14, 2019 | Mar 4, 2020 (actual) |
| NCT03767855 | A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects | Phase 1 | Completed | Dec 4, 2018 | Jan 3, 2020 (actual) |
| NCT04944784 | A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) | Phase 3 | Terminated | Aug 16, 2021 | Jul 18, 2023 (actual) |
| NCT05662215 | A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants | Phase 1 | Terminated | Dec 6, 2022 | Aug 8, 2023 (actual) |
| NCT05442775 | A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) | 3 | Terminated | Aug 4, 2022 | Jun 7, 2023 (actual) |
| NCT05924815 | Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval | Phase 1 | Completed | May 15, 2023 | Nov 14, 2023 (actual) |
| NCT03759392 | Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure | Phase 3 | Completed | Apr 9, 2019 | Nov 8, 2021 (actual) |
| NCT02929329 | Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction | Phase 3 | Completed | Jan 6, 2017 | Sep 14, 2020 (actual) |
| NCT01786512 | COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure | Phase 2 | Completed | Feb 26, 2013 | Jul 22, 2015 (actual) |
| NCT01077167 | Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients | Phase 2 | Withdrawn | 2010-07 | 2011-05 (actual) |
| NCT01737866 | Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency | Phase 1 | Completed | 2012-11 | 2013-01 (actual) |
| NCT04464525 | Omecamtiv Mecarbil Post-trial Access Study | Phase 3 | Withdrawn | Dec 18, 2020 | Nov 27, 2026 (estimated) |
| NCT02601001 | Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese Adults | Phase 1 | Completed | Nov 13, 2015 | Jan 6, 2016 (actual) |
| NCT01300013 | Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF) | Phase 2 | Completed | 2011-04 | 2013-04 (actual) |
| NCT02695420 | Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Apr 14, 2016 | Apr 6, 2017 (actual) |
| NCT02936635 | A Study for Patients Who Completed VITALITY-ALS (CY 4031) | Phase 3 | Completed | Oct 17, 2016 | Oct 26, 2018 (actual) |
| NCT00624442 | A Study of CK-1827452 Infusion in Stable Heart Failure | Phase 2 | Completed | 2007-04 | 2009-02 (actual) |
| NCT03160898 | A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Phase 2 | Completed | Jul 24, 2017 | Mar 7, 2019 (actual) |
| NCT02496767 | Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year | Phase 3 | Completed | Sep 3, 2015 | Mar 9, 2017 (actual) |
| NCT02644668 | A Study of CK-2127107 in Patients With Spinal Muscular Atrophy | Phase 2 | Completed | Jan 14, 2016 | May 31, 2018 (actual) |
| NCT01709149 | Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS) | Phase 2 | Completed | 2012-10 | 2014-03 (actual) |
| NCT00748579 | Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency | II | Terminated | 2008-09 | 2008-11 (actual) |
| NCT00343564 | A Study of SB-743921 in Non-Hodgkin Lymphoma and Hodgkin Lymphoma | Phase 1/Phase 2 | Completed | 2006-04 | 2010-07 (actual) |
| NCT01268280 | Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia Gravis | Phase 2 | Terminated | 2010-12 | 2012-10 (actual) |
| NCT01131013 | A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication | Phase 2 | Completed | 2010-05 | 2011-03 (actual) |
| NCT01089010 | A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Phase 2 | Completed | 2010-03 | 2010-11 (actual) |
| NCT01378676 | A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Phase 2 | Completed | 2011-06 | 2012-03 (actual) |
| NCT00607841 | A Study of Ispinesib in Metastatic Breast Cancer | Phase 1 | Terminated | 2007-12 | 2009-11 (actual) |
| NCT01486849 | Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Phase 2 | Completed | 2011-11 | 2012-03 (actual) |
| NCT00682565 | PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina | Phase 2 | Completed | 2008-04 | 2008-11 (actual) |
| NCT01380223 | A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers | Phase 1 | Completed | 2005-08 | 2006-04 (actual) |
| NCT00941681 | Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart Failure | Phase 2 | Completed | 2009-04 | 2009-10 (actual) |
FDA records (last 2 years)
- FDA New drug/biologic (novel): MYQORZO (aficamten) — NDA219083, Dec 19, 2025. Applicant at approval: Cytokinetics, Incorporated. source ↗
NIH awards 7
- NIH award 3RC3NS070670-01S1 FY2012: $530,523 awarded for that fiscal year; activity RC3 (OTHER_NIH); PI MALIK, FADY; recipient as written: CYTOKINETICS, INC., SOUTH SAN FRANCISCO, CA. Pre-Clinical and Clinical Evalua source ↗
- NIH award 1RC3NS070670-01 FY2010: $2,948,895 awarded for that fiscal year; activity RC3 (OTHER_NIH); PI MALIK, FADY; recipient as written: CYTOKINETICS, INC., SOUTH SAN FRANCISCO, CA. Pre-Clinical and Clinical Evalua source ↗
- NIH award 1R43AI055138-01 FY2003: $100,000 awarded for that fiscal year; activity R43 (SBIR); PI HEKMAT-NEJAD, MOHAMMAD; recipient as written: CYTOKINETICS, INC., SOUTH SAN FRANCISCO, CA. Mitotic Kinesins: Novel Targ source ↗
- NIH award 1R43HL068349-01 FY2001: $99,900 awarded for that fiscal year; activity R43 (SBIR); PI HARTMAN, JAMES JOSEPH; recipient as written: CYTOKINETICS, INC., SOUTH SAN FRANCISCO, CA. A Novel Approach to Identify S source ↗
- NIH award 1R43AI049598-01 FY2001: $100,000 awarded for that fiscal year; activity R43 (SBIR); PI NISLOW, COREY EVAN; recipient as written: CYTOKINETICS, INC., SOUTH SAN FRANCISCO, CA. Actin-binding proteins as novel source ↗
- NIH award 1R43AI048969-01 FY2001: $100,000 awarded for that fiscal year; activity R43 (SBIR); PI NISLOW, COREY EVAN; recipient as written: CYTOKINETICS, INC., SOUTH SAN FRANCISCO, CA. A NOVEL TARGET FOR THE DEVELOPME source ↗
- NIH award 1R43HL066647-01 FY2001: $99,900 awarded for that fiscal year; activity R43 (SBIR); PI MALIK, FADY; recipient as written: CYTOKINETICS, INC., SOUTH SAN FRANCISCO, CA. VALIDATION OF A NOVEL SARCOMERIC HIGH TH source ↗
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