COMPANY

AOBiome

AOBiome Therapeutics is a late stage therapeutics company addressing a broad range of inflammatory skin conditions by harnessing a single strain of Ammonia Oxidizing Bacteria (AOB), a critical part of the nitrogen cycle and by extension the immune system, whose presence as part of the human microbiome has been eliminated through modern living. From company website Source · Oct 13, 2026

Keywords: therapeutics microbiome Acne Vulgaris Atopic Dermatitis Atopic Dermatitis Eczema Pruritus Eczema Allergic Rhinitis Allergic Rhinitis Due to Grass Pollen Migraine Rosacea Prehypertension Stage I Hypertension Keratosis Pilaris B244 Experimental: B244

Profile checked Oct 10, 2026

12Trials (company is sponsor)

Timeline

2026-10 Trial start Phase 2: Study to Determine Efficacy, Safety, and Tolerability of B244 as a Topical Spray in Subjects With Moderate to Severe Acne Vulgaris source ↗
Jun 24, 2020 Trial start Phase 2: B244 Topical Spray for the Treatment of Pruritus in Adults With a History of Atopic Dermatitis source ↗
Dec 7, 2018 Trial start Phase 1: A Study of B244 Delivered as a Topical Spray to Assess Safety in Pediatric Subjects With Atopic Dermatitis source ↗
Jul 2, 2018 Trial start Phase 2: A Study to Determine Safety and Efficacy of B244 in Subjects With Mild to Moderate Rosacea source ↗
Mar 30, 2018 Trial start Phase 2: Study to Determine Safety and Efficacy of B244 in Subjects With Episodic Migraine source ↗
Jan 15, 2018 Trial start Phase 2: Study to Determine Safety and Efficacy of B244 in Subjects With Mild to Moderate Atopic Dermatitis source ↗
Sep 19, 2017 Trial start Phase 1/Phase 2: Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis source ↗
2016-11 Trial start Phase 2: A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure source ↗
2016-08 Trial start Phase 2/Phase 3: Clinical Trial in Subjects With Mild to Moderate Acne Vulgaris source ↗
May 11, 2016 Trial start Not phased (device or behavioral study): Cosmetic Study to Improve the Appearance of Skin Afflicted With Mild to Moderate Atopic Dermatitis. source ↗
Dec 4, 2015 Trial start Not phased (device or behavioral study): Cosmetic Study of AO+Mist in Improving the Appearance of Skin Afflicted With Keratosis Pilaris source ↗
Aug 5, 2015 Trial start Phase 1/Phase 2: A Double Blind, Placebo-Controlled, Randomized Study in Subjects With Acne Vulgaris source ↗

Upcoming milestones

2027-08 (ESTIMATED) · Phase 2 · Study to Determine Efficacy, Safety, and Tolerability of B244 as a Topical Spray in Subjects With Moderate to Severe Acne Vulgaris · NCT07866105

Estimated primary completion per ClinicalTrials.gov. Dates move.

Clinical trials (lead sponsor) 12

Record	Title	Phase	Status	Start	Primary completion
NCT07866105	Study to Determine Efficacy, Safety, and Tolerability of B244 as a Topical Spray in Subjects With Moderate to Severe Acne Vulgaris	Phase 2	Not yet recruiting	2026-10	2027-08 (estimated)
NCT04490109	B244 Topical Spray for the Treatment of Pruritus in Adults With a History of Atopic Dermatitis	Phase 2	Completed	Jun 24, 2020	Dec 10, 2021 (actual)
NCT03775434	A Study of B244 Delivered as a Topical Spray to Assess Safety in Pediatric Subjects With Atopic Dermatitis	Phase 1	Completed	Dec 7, 2018	May 18, 2019 (actual)
NCT03290248	Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis	Phase 1/Phase 2	Completed	Sep 19, 2017	Dec 21, 2018 (actual)
NCT03235024	Study to Determine Safety and Efficacy of B244 in Subjects With Mild to Moderate Atopic Dermatitis	Phase 2	Completed	Jan 15, 2018	Feb 27, 2019 (actual)
NCT03488563	Study to Determine Safety and Efficacy of B244 in Subjects With Episodic Migraine	Phase 2	Completed	Mar 30, 2018	Jun 17, 2019 (actual)
NCT03590366	A Study to Determine Safety and Efficacy of B244 in Subjects With Mild to Moderate Rosacea	Phase 2	Completed	Jul 2, 2018	Feb 11, 2019 (actual)
NCT02832063	Clinical Trial in Subjects With Mild to Moderate Acne Vulgaris	Phase 2/Phase 3	Completed	2016-08	Jul 19, 2017 (actual)
NCT02998840	A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure	Phase 2	Completed	2016-11	Apr 25, 2017 (actual)
NCT03268174	Cosmetic Study to Improve the Appearance of Skin Afflicted With Mild to Moderate Atopic Dermatitis.	Not phased (device or behavioral study)	Completed	May 11, 2016	Feb 13, 2017 (actual)
NCT03243617	Cosmetic Study of AO+Mist in Improving the Appearance of Skin Afflicted With Keratosis Pilaris	Not phased (device or behavioral study)	Completed	Dec 4, 2015	Jun 8, 2016 (actual)
NCT02656485	A Double Blind, Placebo-Controlled, Randomized Study in Subjects With Acne Vulgaris	Phase 1/Phase 2	Completed	Aug 5, 2015	Mar 1, 2016 (actual)