COMPANY

Applied Biologics

Profile checked Oct 10, 2026

Keywords: Diabetic Foot Ulcer Diabetic Foot Foot Ulcer Ulcer Foot Pressure Ulcer Amniotic Membrane Placental Allograft Biologic Foot Ulcer Due to Type 2 Diabetes Mellitus Foot Ulcer Due to Type 1 Diabetes Mellitus Pressure Wound Pressure Area Diabetic Foot Ulcers Foot Ulcer Chronic Ulcer Knee Osteoarthritis Rotator Cuff Tear Fatty Atrophy mHACMb

7Trials (company is sponsor)

Timeline

Oct 8, 2026 Trial start Phase 3: a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Di source ↗
Oct 16, 2025 Trial start —: Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial. source ↗
Aug 26, 2025 Trial start Phase 4: A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ul source ↗
Jun 11, 2025 Trial start Phase 4: A Multicenter, Prospective, Clinical Trial Evaluating a Single Layer Amniotic Membrane and Standard of Care Versus Matched Controls in the Management of Nonhealing Pressure Ulcers source ↗
Sep 20, 2024 Trial start Not phased (device or behavioral study): Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care Versus Standard of Care source ↗
2018-11 Trial start Phase 2: Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee source ↗
Mar 24, 2017 Trial start Not phased (device or behavioral study): Efficacy of an Amniotic Fluid Derived Allograft, (FlōGraft®) in Rotator Cuff Repairs: A Prospective Study source ↗

Upcoming milestones

2027-08 (ESTIMATED) · Phase 4 · A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers · NCT07159282
2027-08 (ESTIMATED) · Phase 4 · A Multicenter, Prospective, Clinical Trial Evaluating a Single Layer Amniotic Membrane and Standard of Care Versus Matched Controls in the Management of Nonhealing Pressure Ulcers · NCT07126886
2027-10 (ESTIMATED) · · Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial. · NCT07360418
2028-11 (ESTIMATED) · Phase 3 · a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Fo · NCT07852338

Estimated primary completion per ClinicalTrials.gov. Dates move.

Clinical trials (lead sponsor) 7

Record	Title	Phase	Status	Start	Primary completion
NCT07852338	a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers	Phase 3	Recruiting	Oct 8, 2026	2028-11 (estimated)
NCT07159282	A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers	Phase 4	Recruiting	Aug 26, 2025	2027-08 (estimated)
NCT07126886	A Multicenter, Prospective, Clinical Trial Evaluating a Single Layer Amniotic Membrane and Standard of Care Versus Matched Controls in the Management of Nonhealing Pressure Ulcers	Phase 4	Recruiting	Jun 11, 2025	2027-08 (estimated)
NCT07360418	Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial.	Not listed	Recruiting	Oct 16, 2025	2027-10 (estimated)
NCT06564831	Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care Versus Standard of Care	Not phased (device or behavioral study)	Recruiting	Sep 20, 2024	2025-02 (estimated)
NCT03441607	Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee	Phase 2	Unknown status (ClinicalTrials.gov)	2018-11	2019-02 (estimated)
NCT03379324	Efficacy of an Amniotic Fluid Derived Allograft, (FlōGraft®) in Rotator Cuff Repairs: A Prospective Study	Not phased (device or behavioral study)	Unknown status (ClinicalTrials.gov)	Mar 24, 2017	Sep 30, 2019 (estimated)