COMPANY

TransMedics

HQ: Andover, MA source · transmedics.com ↗

Location: Andover, MA · source · Oct 15, 2026

Profile checked Oct 10, 2026

Keywords: Heart Transplant Lung Transplant Liver Transplant Transplant Lung Transplantation Liver Transplantation Liver Preservation for Transplant Lung Preservation Bronchiolitis Obliterans Heart Failure Liver Preservation OCS Heart OCS Lung System OCS Heart System OCS Liver OCS Liver System OCS Lung Preservation OCS Lung OCS™ Liver System

26Trials (company is sponsor)

Timeline

2026-03 Trial start Not phased (device or behavioral study): Decreasing Edema With a Novel OCS Solution Trial source ↗
2026-01 Trial start Not phased (device or behavioral study): Enhancing Heart Allograft Function With the OCS Heart System Trial source ↗
Jan 23, 2025 Trial start —: US National TOP Registry source ↗
Aug 25, 2023 Trial start —: US National OCS Heart Perfusion (OHP) Registry source ↗
Oct 14, 2021 Trial start —: OCS Liver Perfusion (OLP) Post-Approval Registry source ↗
Oct 14, 2021 Trial start —: US National OCS Liver Perfusion (OLP) Registry source ↗
Sep 13, 2021 Trial start —: OCS Heart Perfusion Post-Approval Registry source ↗
Nov 25, 2020 Trial start Not phased (device or behavioral study): Donor After Circulatory Death Heart CAP Trial source ↗
Jul 24, 2020 Trial start Not phased (device or behavioral study): OCS Liver DCD Trial source ↗
Feb 3, 2020 Trial start Not phased (device or behavioral study): OCS Liver PROTECT Continued Access Protocol source ↗
Feb 3, 2020 Trial start —: OCS Liver PROTECT Continued Access Protocol (CAP) Continuation Post-Approval Study source ↗
Nov 26, 2019 Trial start —: OCS DCD Heart + CAP Continued Follow-Up source ↗
Nov 26, 2019 Trial start Not phased (device or behavioral study): Donors After Circulatory Death Heart Trial source ↗
Jun 30, 2019 Trial start —: INSPIRE Continuation Post-Approval Study source ↗
Apr 17, 2019 Trial start Not phased (device or behavioral study): Heart EXPAND Continued Access Protocol source ↗
Dec 31, 2018 Trial start —: OCS Lung Expand Post-Approval Study - Expand Follow-Up Data Collection source ↗
Dec 10, 2018 Trial start —: OCS™ Lung TOP Registry For Donor Lungs for Transplantation source ↗
Mar 12, 2018 Trial start Not phased (device or behavioral study): OCS Lung System EXPAND II Trial source ↗
2016-05 Trial start Not phased (device or behavioral study): Trial of the TransMedics Organ Care System™ Liver For Preserving and Assessing Donor Livers for Transplantation source ↗
Jan 24, 2016 Trial start —: OCS Liver PROTECT Continuation Post-Approval Study source ↗
Jan 24, 2016 Trial start Not phased (device or behavioral study): OCS Liver PROTECT Trial: Preserving and Assessing Donor Livers for Transplantation source ↗
Sep 16, 2015 Trial start —: OCS Heart EXPAND + CAP Continued Follow-Up source ↗
Sep 16, 2015 Trial start Not phased (device or behavioral study): International EXPAND Heart Pivotal Trial source ↗
2013-11 Trial start Not phased (device or behavioral study): International EXPAND Lung Pivotal Trial source ↗
2011-11 Trial start Not phased (device or behavioral study): International Randomized Study of the TransMedics Organ Care System (OCS Lung) for Lung Preservation and Transplantation source ↗

Showing 25 of 26 dated events.

Upcoming milestones

2026-10 (ESTIMATED) · · OCS DCD Heart + CAP Continued Follow-Up · NCT05741723
Jan 30, 2027 (ESTIMATED) · Not phased · Enhancing Heart Allograft Function With the OCS Heart System Trial · NCT07145515
2027-12 (ESTIMATED) · Not phased · Decreasing Edema With a Novel OCS Solution Trial · NCT07340710
Aug 31, 2029 (ESTIMATED) · · US National OCS Heart Perfusion (OHP) Registry · NCT05915299
2031-10 (ESTIMATED) · · US National OCS Liver Perfusion (OLP) Registry · NCT05940857
2034-11 (ESTIMATED) · · US National TOP Registry · NCT06513091

Estimated primary completion per ClinicalTrials.gov. Dates move.

Clinical trials (lead sponsor) 26

Record	Title	Phase	Status	Start	Primary completion
NCT05741723	OCS DCD Heart + CAP Continued Follow-Up	Not listed	Active, not recruiting	Nov 26, 2019	2026-10 (estimated)
NCT07340710	Decreasing Edema With a Novel OCS Solution Trial	Not phased (device or behavioral study)	Not yet recruiting	2026-03	2027-12 (estimated)
NCT07145515	Enhancing Heart Allograft Function With the OCS Heart System Trial	Not phased (device or behavioral study)	Recruiting	2026-01	Jan 30, 2027 (estimated)
NCT05915299	US National OCS Heart Perfusion (OHP) Registry	Not listed	Recruiting	Aug 25, 2023	Aug 31, 2029 (estimated)
NCT05047068	OCS Heart Perfusion Post-Approval Registry	Not listed	Active, not recruiting	Sep 13, 2021	2025-12 (estimated)
NCT04194437	OCS Liver DCD Trial	Not phased (device or behavioral study)	Terminated	Jul 24, 2020	Mar 22, 2022 (actual)
NCT06513091	US National TOP Registry	Not listed	Recruiting	Jan 23, 2025	2034-11 (estimated)
NCT03639025	OCS™ Lung TOP Registry For Donor Lungs for Transplantation	Not listed	Active, not recruiting	Dec 10, 2018	Nov 30, 2025 (estimated)
NCT05074160	OCS Liver Perfusion (OLP) Post-Approval Registry	Not listed	Active, not recruiting	Oct 14, 2021	Mar 22, 2024 (actual)
NCT05096299	OCS Heart EXPAND + CAP Continued Follow-Up	Not listed	Active, not recruiting	Sep 16, 2015	2026-08 (estimated)
NCT02323321	International EXPAND Heart Pivotal Trial	Not phased (device or behavioral study)	Completed	Sep 16, 2015	Apr 25, 2018 (actual)
NCT03835754	Heart EXPAND Continued Access Protocol	Not phased (device or behavioral study)	Completed	Apr 17, 2019	Sep 15, 2021 (actual)
NCT05940857	US National OCS Liver Perfusion (OLP) Registry	Not listed	Recruiting	Oct 14, 2021	2031-10 (estimated)
NCT04186221	OCS Liver PROTECT Continued Access Protocol	Not phased (device or behavioral study)	Completed	Feb 3, 2020	Feb 2, 2021 (actual)
NCT04615182	Donor After Circulatory Death Heart CAP Trial	Not phased (device or behavioral study)	Completed	Nov 25, 2020	Dec 21, 2021 (actual)
NCT03831048	Donors After Circulatory Death Heart Trial	Not phased (device or behavioral study)	Completed	Nov 26, 2019	Apr 1, 2021 (actual)
NCT03343535	OCS Lung System EXPAND II Trial	Not phased (device or behavioral study)	Terminated	Mar 12, 2018	Aug 27, 2019 (actual)
NCT05096741	OCS Liver PROTECT Continuation Post-Approval Study	Not listed	Completed	Jan 24, 2016	Nov 5, 2021 (actual)
NCT05096754	OCS Liver PROTECT Continued Access Protocol (CAP) Continuation Post-Approval Study	Not listed	Completed	Feb 3, 2020	Feb 2, 2023 (actual)
NCT02522871	OCS Liver PROTECT Trial: Preserving and Assessing Donor Livers for Transplantation	Not phased (device or behavioral study)	Completed	Jan 24, 2016	Oct 22, 2019 (actual)
NCT01630434	International Randomized Study of the TransMedics Organ Care System (OCS Lung) for Lung Preservation and Transplantation	Not phased (device or behavioral study)	Completed	2011-11	2014-09 (actual)
NCT01963780	International EXPAND Lung Pivotal Trial	Not phased (device or behavioral study)	Completed	2013-11	Nov 22, 2016 (actual)
NCT04194398	OCS Lung Expand Post-Approval Study - Expand Follow-Up Data Collection	Not listed	Completed	Dec 31, 2018	Sep 30, 2021 (actual)
NCT03868904	INSPIRE Continuation Post-Approval Study	Not listed	Completed	Jun 30, 2019	Oct 12, 2021 (actual)
NCT00855712	Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation	Not phased (device or behavioral study)	Completed	2009-03	2013-10 (actual)
NCT02449694	Trial of the TransMedics Organ Care System™ Liver For Preserving and Assessing Donor Livers for Transplantation	Not phased (device or behavioral study)	Completed	2016-05	Sep 19, 2017 (actual)